ichair@ed.ac.uk

News

ICHAIR publications

Theme One

Singh BK, Savill NJ, Ferguson NM, Robertson C and Woolhouse MEJ. Rapid detection of pandemic influenza in the presence of seasonal influenza. BMC Public Health 2010, 10:726 doi:10.1186/1471-2458-10-726.

Pybus OG, Rambaut A. Modelling: Evolutionary analysis of the dynamics of viral infectious disease. Nat Rev Genet. 2009 Jun 30. [Epub ahead of print]

Smith GJ, Vijaykrishna D, Bahl J, Lycett SJ, Worobey M, Pybus OG, Ma SK, Cheung CL, Raghwani J, Bhatt S, Peiris JS, Guan Y, Rambaut A. Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic. Nature. 2009 Jun 25;459(7250):1122-5.

Fraser C, Donnelly CA, Cauchemez S, Hanage WP, Van Kerkhove MD, Hollingsworth TD, Griffin J, Baggaley RF, Jenkins HE, Lyons EJ, Jombart T, Hinsley WR, Grassly NC, Balloux F, Ghani AC, Ferguson NM, Rambaut A, Pybus OG, Lopez-Gatell H, Alpuche-Aranda CM, Chapela IB, Zavala EP, Guevara DM, Checchi F, Garcia E, Hugonnet S, Roth C, WHO Rapid Pandemic Assessment Collaboration. Pandemic potential of a strain of influenza A (H1N1): early findings. Science. 2009 Jun 19;324(5934):1557-61. Epub 2009 May 11.

Rambaut A, Pybus OG, Nelson MI, Viboud C, Taubenberger JK, Holmes EC. The genomic and epidemiological dynamics of human influenza A virus. Nature. 2008 May 29;453(7195):615-9.

Savill NJ, St Rose SG, Woolhouse ME. Detection of mortality clusters associated with highly pathogenic avian influenza in poultry: a theoretical analysis. J R Soc Interface. 2008 May 13.

Kosakovsky Pond SL, Poon AF, Leigh Brown AJ, Frost SD. A maximum likelihood method for detecting directional evolution in protein sequences adn its application to influenza A virus. Mol Biol Evol. 2008 Sep;25(9): 1809-24.

Pre-ICHAIR publications on influenza virus

Savill NJ, St Rose SG, Keeling MJ, Woolhouse ME. Silent spread of H5N1 in vaccinated poultry. Nature. 2006 Aug 17;442(7104):757.

Theme Two

S Franz, MA Hoeve, S Wickert, C Janko, I Dransfield. Clearance of apoptotic neutrophils induces an immunosuppressive response in pro-inflammatory type-1 and anti-inflammatory type-2 macrophages. Autoimmunity 2009;4:275-277.

Hale BG, Randall RE, Ortin J, Jackson D. The multifunctional NS1 protein of influenza A viruses. J Gen Virol. 2008 Oct;89(Pt10):2359-76.

Hale BG, Batty IH, Downes CP, Randall RE. Binding of influenza A virus NS1 protein to the inter-SH2 domain of p85 suggests a novel mechanism for phosphoinositide 3-kinase activation. J Biol Chem. 2008 Jan 18;283(3):1372-80.

Pre-ICHAIR publications on influenza virus

Hale BG, Randall RE. P13K signalling during influenza A virus infections. Biochem Soc Trans. 2007 Apr;35(Pt2):186-7.

Hale BG, Jackson D, Chen YH, Lamb RA, Randall RE. Influenza A virus NS1 protein binds p85beta and activates phosphatidylisnositol-3-kinase signaling. Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14194-9.

Bissonnette ML, Connolly SA, Young DF, Randall RE, Paterson RG, Lamb RA. Analysis of the pH requirement for membrane fusion of different isolates of the paramyxovirus parainfluenza virus 5. J Virol. 2006 Mar;80(6):3071-7.

Theme Three

Collins PJ, Haire LF, Lin YP, Liu J, Russell RJ, Walker PA, Skehel JJ, Martin SR, Hay AJ, Gamblin SJ. Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants. Nature. 2008 Jun 26;453(7199):1258-61.

Hale BG, Barclay WS, Randall RE, Russell RJ. Structure of an avian influenza A virus NS1 protein effector domain. Virology. 2008 Aug 15;378(1):1-5.

Li SN, Lee BJ, Langley WA, Bradley KC, Russell RJ, Steinhauer DA. Length requirements for membrane fusion of influenza virus hemmagglutin peptide linkers to transmembrane or fusion peptide domains. J Virol. 2008 Jul;82(13):6337-48.

Nicholls JM, Chan RW, Russell RJ, Air GM, Peiris JS. Evolving complexities of influenza virus and its receptors. Trends Microbiol. 2008 Apr;16(4):149-57.

Meisner J, Szretter KJ, Bradley KC, Langley WA, Li ZN, Lee BJ, Thoennes S, Martin J, Skehel JJ, Russell RJ, Katz JM, Steinhauer DA. Infectivity studies of influenza virus hemmagglutinin receptor binding site mutants in mice. J Virol. 2008 May;82(10):5079-83.

Thoennes S, Li ZN, Lee BJ, Langley WA, Skehel JJ, Russell RJ, Steinhauer DA. Analysis of residues near the fusion peptide in the influenza hemagglutinin structure for roles in triggering membrane fusion. Virology. 2008 Jan 20;370(2):403-14.

Pre-ICHAIR publications on influenza virus

Yamada S, Suzuki Y, Suzuki T, Le MQ, Nidom CA, Sakai-Tagawa Y, Muramoto Y, Ito M, Kiso M, Horimoto T, Shinya K, Sawada T, Kiso M, Usui T, Murata T, Lin Y, Hay A, Haire LF, Stevens DJ, Russell RJ, Gamblin SJ, Skehel JJ, Kawaoka Y. Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors. Nature. 2006 Nov 16;444(7117):378-82.